Isixhobo se-Optofluidic Sivumela ukubonwa kweeMolekyu eziNye

BREISGAU, eJamani, ngoNovemba 10, 2021 - Ukucaphula ukwanda kokuchasana kwe-antibiotics ekunyukeni kwihlabathi, abaphandi abavela kwiFraunhofer Institute for Physical Measurement Techniques (Fraunhofer IPM), esebenza kunye nabo baseLudwig Maximilian University yaseMunich, baye baphuhlisa inkqubo ngokukhawuleza. ukufumanisa iintsholongwane ezinganyangekiyo ngamachiza amaninzi. Indlela inobuthathaka ngokwaneleyo ukuba ikwazi ukusebenzisa imolekyuli enye ye-DNA ukubhaqa i-pathogen.

Ukufumana eyona antibiotic isebenzayo kufuna ulwazi malunga nejenome yebhaktiriya, engafumanekiyo kunyango. Uvavanyo lwaseLab luyafuneka ngokwesiqhelo, nto leyo eyongeza ixesha kunye nobunzima kukhangelo. Indlela ephuhliswe ngabaphandi ikhawuleza inkqubo, isebenzisa i-microfluidic chip ukuze ibone kwaye ihlalutye iamolekyu enye. Ugxininiso lweprojekthi ye-SiBoF (ii-boosters zesignali ze-fluorescence assays kwi-molecular diagnostics) ilele kwindlela yokufumanisa indawo ekulula ukuyisebenzisa. Abaphandi balindele ukuba iqonga lisetyenziswe njengenxalenye ye-point-of-care diagnostics kwiiwadi zesibhedlele okanye kwiinkqubo zonyango njengenye indlela esekelwe kuhlalutyo lwe-polymerase chain reaction.
Isixhobo esibambeneyo sokubona iintsholongwane ezinganyangekiyo ngamachiza zenza zonke izigaba zokusabela ngokuzenzekelayo kwaye zibonelela ngesiphumo kwiyure enye. Nokuba imolekyuli enye ye-DNA yanele ukubonwa. Ngoncedo lweFraunhofer IPM
Iqela labaphandi eJamani liye laqulunqa inkqubo yokukhangela ngokukhawuleza iintsholongwane ezikwaziyo ukumelana namayeza amaninzi. Inkqubo isebenzisa i-compact device eyenza zonke izigaba zokuphendula ngokuzenzekelayo kwaye inikeze umphumo kwiyure enye. Nokuba imolekyuli enye ye-DNA yanele ukubonwa. Ngoncedo lweFraunhofer IPM.
I-portable, i-compact test platform ixhotywe nge-automated fluidic system, apho zonke ii-reagents eziyimfuneko zigcinwa. I-injection-molded microfluidic chip ifakwe kwi-drawer kwinkqubo yokuvavanya, apho inikezelwa ngee-reagents eziyimfuneko ngokusebenzisa inkqubo ye-fluidic ngaphambi kokuba uhlalutyo lwe-optical lwenzeke.

“Sibhaqa inxalenye ye-DNA strand ye-pathogen. Ukusebenzisa inkqubo yethu entsha, nemolekyuli enye ye-DNA ebophelela kwindawo ethile kwi-microfluidic chip yanele ukwenza oku. Imijelo ye-Fluidic idityaniswe kwi-chip - iindawo eziphantsi kwayo zixutywe kunye neziza ezibophelelayo kwiintsholongwane ezithile, "kuchaza uBenedikt Hauer, umphathi weprojekthi kunye nososayensi wophando kwiFraunhofer IPM.

Isixhobo esinendawo yokunyamekela sibonisa i-microscope encinci ye-high-resolution fluorescence. Isoftware yohlahlelo lwemifanekiso ephuhliswe ngokukodwa ichonga iimolekyuli enye, eyenza ukuba iimolekyuli ekujoliswe kuzo zibalwe ukuhambisa isiphumo sobungakanani. I-fluorescence ivuselelwe kusetyenziswa ii-LED, ezifakwe ngaphantsi kwekhatriji equlethe iziteshi ezimanzi.

Ngokuqhelekileyo, iimolekyuli ze-DNA ekujoliswe kuzo zichongwa ngokusebenzisa iimpawu ezithile ze-fluorescence. Indlela entsha isebenzisa ii-antenna ezinobungakanani be-nanometer-size beads, ezikhulisa izibonakaliso ze-optical zala makishi kwaye ziphelise ukuthembela kwi-chemical amplification nge-PCR.

"Ii-antenna ze-optical zibandakanya i-nanometer-size-particle yentsimbi egxininise ekukhanyeni kwindawo encinci kwaye inceda ekukhupheni ukukhanya - njengokuba ii-antenna ezinkulu zenza ngamaza erediyo," utshilo u-Hauer. Amasuntswana esinyithi adityaniswe ngamachiza kumphezulu wetshiphu.

Isakhiwo seemolekyuli ze-DNA, apho abaphandi bachaza njenge-origami ye-DNA, ibamba zombini i-nanoparticles yegolide kwindawo. Phakathi kwe-nanoparticles, isakhiwo sinikezela indawo yokubopha i-molecule ejoliswe kuyo kunye ne-fluorescence marker. Uyilo olunelungelo elilodwa lomenzi lubonelela ngesiseko setekhnoloji yovavanyo lwenoveli.


Ixesha lokuposa: Dec-14-2021


Leave Your Message